Micky van de Ven Brace Ends The Toffees' Run at New Stadium
The Dutch defender became the first defender to net twice in a English top-flight match for Tottenham since Jan Vertonghen in spring 2013.
Match summary
The Spurs defender nods into the net two times in first half
Everton's Jake O'Brien has equalizer ruled after video check
Senegalese midfielder scores final goal in 89th minute
This loss is the Merseyside club's initial at their new ground
The Tottenham defender found the net on two occasions as Spurs prolonged their winning streak on the road in the top division and delivered the Toffees their first defeat at Hill Dickinson Stadium.
Everton were undefeated in their five previous fixtures at their new ground at the dockside location, having left their historic home behind after 133 years at the end of last season.
But Tottenham's leader the Dutchman pounced twice from corners in the opening 45 minutes to place their impressive record at jeopardy, and they were unable to mount a comeback before Pape Matar Sarr - assisted by ex-Everton forward Richarlison - headed home a final goal to put the game to bed.
The Everton defender thought he had levelled the tally a short while after the defender's opener, glancing a bullet header past the Spurs keeper from an set-piece.
Beto, meanwhile, failed to convert a handful of opportunities, while the Italian goalkeeper made a series of excellent stops to ensure the London club went five matches on the road unbeaten in the English top flight.
But the video assistant referee intervened, instructing Craig Pawson to review the goal on the screen and the official ruled that the winger and the attacker were in offside positions and had impeded with the Spurs keeper.
This victory moves Thomas Frank's side into third place in the Premier League, five points off local foes and table-toppers Arsenal.
Everton stay 14th and sit six points clear of the drop zone.
Spurs breakdown: The defender fulfils role at each end of pitch
Following a uninspiring midweek display in the Champions League against the French side, where they managed a only attempts on target, the manager opted for the French striker up front instead of ex-Everton forward the Brazilian.
The summer signing was unable to make much of an impact before being replaced for Richarlison after an hour on the pitch, but it turns out he wasn't needed in the final outcome.
Centre-back the Dutchman transformed into an offensive threat to be reckoned with.
Spurs' opening strike came from a cleverly executed set-piece play, with Rodrigo Bentancur directing the ball back across the six-yard box for an unmarked Van de Ven to head home.
And the captain - stepping up as skipper in Cristian Romero's absence - notched his next goal in first-half stoppage time as he outjumped the England keeper to nod in.
The Dutchman was equally impressive in defensive duties, combining effectively with Kevin Danso as the pair handled excellently with the numerous deliveries thrown their way by the opposition.
Toffees breakdown: Toffees missing striker's instinct
Everton's new home had been a happy hunting ground, but it seems the novelty may have faded slightly and supporters flocked to the gates after Sarr's final goal for Tottenham.
The break in the team's unbeaten home run will not be a massive concern for the manager, but their striker situation are.
Beto and Thierno Barry - the Toffees' two established strikers - had netted only a single goal combined before Sunday's match.
And they were failed to contribute to that poor record on a damp and dreary evening on in Liverpool.
Beto's form was summed up when he opted to bicycle-kick a clear chance from near the goal, despite having space and opportunity to reposition for a more conventional shot that would have tested Vicario.
Barry, as well, failed to influence the game after replacing the starter in the 65th minute.
It wasn't for a lack of opportunity. The majority of Everton's attacks came through the winger and the forward, who relentlessly delivered dangerous crosses into the Tottenham box.
What next for both teams?
The Toffees: The team travel to the Stadium of Light in the Premier League on early November at 8 PM.
Tottenham: Spurs travel to St James' Park on late October for their fourth-round Carabao Cup match against Newcastle.